Bulk Bromantane Powder API
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Wholesale Sourcing Ordering Requirements. We specialize in high-purity wholesale bromantane powder for industrial applications and analytical research. Because we cater exclusively to commercial and laboratory clients, all orders are subject to a minimum order quantity (MOQ) of 3.0 kg. Contact our logistics team today to request a quote, verify current batch availability, or arrange international freight shipping.
Where to Buy Bulk Bromantane for Business Research. If you are looking for a reliable wholesale supplier to buy bulk bromantane, or industrial supply of wholesale bromantane for reference laboratory research. Linuset provides premium, commercial-scale inventory. We operate strictly as a B2B chemical supplier, offering competitive bulk pricing for laboratories, manufacturing facilities, and institutional buyers who require consistent, large-scale raw material sourcing.
Industrial Wholesale Sourcing Compliance.
Linuset is a premier industrial supplier of wholesale bromantane for reference laboratory research and commercial manufacturing. Our high-purity crystalline solid is distributed exclusively as an analytical reference standard and raw chemical intermediate. We do not sell retail consumer fractions; all distribution routes are restricted to verified institutional buyers, testing laboratories, and B2B manufacturing facilities.
Resolving Structural Impurities & Downstream Formulation Failures
Standard commodity-grade Bromantane imports frequently experience major downstream quality control failures during laboratory compounding. These structural shortcomings stem directly from incomplete chemical processes, rushed synthesis metrics, and primitive static atmospheric tray-drying models.
During industrial production pathways involving the reductive amination of adamantan-2-one with 4-bromoaniline, static drying methodologies cause the external crystalline framework to crust over. This phenomenon leaves problematic solvent clathrates physically locked within the lipophilic, cage-like interstitial voids of the adamantyl core matrix. The result is an organoleptic failure exhibiting a pungent, synthetic chemical odor that damages mucosal membranes, ruins sublingual formulations, and prompts immediate batch rejection.
Furthermore, standard high-performance liquid chromatography (HPLC) methods operating strictly at 245 nm or 254 nm possess a significant analytical blindspot. The crucial synthetic intermediate adamantan-2-one lacks a conjugated chromophore, rendering it functionally invisible under single-wavelength ultraviolet detection protocols. Low-tier distributors consistently misreport purity balances because their quality control framework lacks the multi-wavelength capacity to track hidden unreacted precursors.
The Linuset Purity Advantage
To thoroughly clear deep crystal lattice entrapment, Linuset routes all raw production matrices through a rigorous multi step recrystallisation processing workflow.
Removing solvents entail every batch being loaded into an industrial-scale Büchi 20L Rotary Vacuum Evaporator for an exhaustive 120-minute continuous mechanical tumbling protocol under deep dynamic vacuum thresholds.
This desolvation process suppresses residual ethyl acetate below standard human olfactory detection barriers (<5 ppm), yielding a stable, completely odorless microcrystalline solid. This structural profile guarantees seamless, irritation-free compounding performance.
Certified Reference Batch Specifications (Lot Reference: SL2020/2-13)
| Analytical Parameter | Testing Methodology | Acceptance Threshold | Observed Metric | Compliance Status |
|---|---|---|---|---|
| Chromatographic Purity | External RP-HPLC (Multi-Channel DAD) | ≥ 99.50% Integrated Area | 100.00% Area Purity | PASS |
| Structural Concordance | High-Field 400 MHz 1H-NMR (CDCl3) | Matches Theoretical Structure | Conforms (Exact Proton Balance) | PASS |
| Physical Form | Visual Organoleptic Verification | Pure White Crystalline Solid | Conforms (White Microcrystals) | PASS |
| Odor Profile | Olfactory Sensory Panel | Odorless (<5 ppm Volatiles) | Conforms (Zero Solvent Notes) | PASS |
| Melting Range | Capillary Transition Apparatus | 105.0 °C – 108.0 °C | 106.2 °C – 107.4 °C (Sharp) | PASS |
| 4-Bromoaniline Precursor | RP-HPLC / 1H-NMR Audit | Not Detected (< 0.05% w/w) | Zero Signal (Not Detected) | PASS |
| Adamantan-2-one Reagent | High-Field 1H-NMR (2.58 ppm) | Not Detected (< 0.05% w/w) | Flat Baseline (Not Detected) | PASS |
| Residual Ethyl Acetate | 1H-NMR (4.12 ppm Track) | Sub-ICH Class 3 Limit | Undetectable (<5 ppm Olfactory) | PASS |
| Loss on Drying (LOD) | Thermal Vacuum Desiccation | ≤ 0.50% w/w | 0.08% w/w | PASS |
HPLC reslults for Linuset Bromantane
1H NMR results for Linuset Bromantane
Orthogonal RP-HPLC & 1H-NMR Testing Parameters
To secure total transparent validation, Linuset utilizes dual-instrument orthogonal clearance conducted via independent, certified laboratory facilities:
| Analytical Instrument | Operational Parameters & Chromatographic / Spectroscopic Signatures |
|---|---|
| RP-HPLC Analysis |
Column: Waters XBridge C18 (5 µm, 150 × 4.6 mm) | Flow Rate: 0.6 mL/min Mobile Phase: Channel A: 0.1% Formic Acid in Water / Channel B: 100% Acetonitrile Gradient Profile: 0–2 min at 40% B, linear ramp to 100% B at 12 min, hold to 23 min Detection Channels: DAD 245 nm (Aromatic Maxima) & DAD 210 nm (Universal End-Absorption) Retention Profile: Primary Bromantane Peak resolved cleanly at tR: 17.32 min. Zero precursors or breakdown products detected across the complete run. |
| 1H-NMR Spectroscopy |
System: Bruker Avance 400 MHz spectrometer operating in CDCl3 at 294.5 K. Observed Proton Resonance Envelopes: • δ 7.222 ppm (Doublet, J ≈ 8.8 Hz, 2H): Aromatic C-H ortho to Bromine substituent. • δ 6.477 ppm (Doublet, J ≈ 8.8 Hz, 2H): Aromatic C-H ortho to Secondary Amine. • δ 4.007 ppm (Broad Singlet, 1H): Secondary Amine (-NH-) proton bond. • δ 3.486 ppm (Singlet, 1H): Adamantyl Methine (C2-H) bridgehead linkage. • δ 1.58 – 2.01 ppm (Multiplet Envelope, 14H): Rigid Adamantane core mass balance. Purity Status: Absolute baseline flatness verified at δ 2.58 ppm (Ketone), δ 3.60 ppm (Aniline), and δ 4.12 ppm (Ethyl Acetate). |
RP-HPLC Trace Verification
High-Field 1H-NMR Spectrum Verification
Quantified Organic Solubility Matrix (Ambient 25 °C)
Understanding the distinct solubility characteristics of this highly lipophilic compound (Calculated Log P = 4.65) is critical for downstream chemical processing, master batch preparations, and designing high-stability compounding architectures. Bromantane displays negligible dissolution within aqueous mediums while demonstrating optimal saturation values across organic carriers and lipid vehicles:
| Compounding Solvent / Medium | Empirical Value | Target Formulation Framework |
|---|---|---|
| Dimethyl Sulfoxide (DMSO) | > 85.0 mg/mL | Analytical control standard and stock chemical reagent assays. |
| Ethanol (200 Proof / Absolute USP) | 42.0 – 48.0 mg/mL | Primary clearing and dissolving agent for concentrated master batching. |
| Polyethylene Glycol 400 (PEG-400) | 32.0 – 36.0 mg/mL | High-density non-lipid base engineered for heavy active volumes without oily mouthfeel. |
| Medium Chain Triglycerides (MCT Oil) | 18.0 – 22.0 mg/mL | Standard lipophilic oil carrier utilized for high-stability sublingual drops. |
| Pure Caprylic Acid (C8) Triglyceride | 12.0 – 15.0 mg/mL | Low-viscosity functional carrier system for fast-acting intranasal spray configurations. |
| Purified Water (USP Grade) / Saline | < 0.005 mg/mL | Practically insoluble. Demands advanced high-shear mechanical suspension processing. |
Industrial Packaging, Storage Safeguards, & Freight Compliance
Every 1,000 g industrial consignment is packed using strict physical storage criteria:
- Containment: Sealed under absolute vacuum settings.
- Warehouse Storage: Maintained within controlled ambient environments (15 °C to 25 °C). Do not freeze. Keep isolated from direct ultraviolet paths and moisture ingress. Recommended re-test life cycle is 24 months.
- Freight Logistics: Fully compliant with standard GHS 16-section SDS parameters. Classified as a non-hazardous chemical powder across all global road, air freight, and maritime commercial channels (US DOT, IATA, ICAO, and IMDG freight lines).
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